Thursday, April 07, 2011
The maximum dose of HCTZ for the treatment of hypertension is typically listed as 50 mg per day. However, there is minimal "bang for the buck" for doses over 25 mg. In some studies, increasing the dose from 25 mg to 50 mg only reduced the systolic blood pressure by 4 mm. In my private practice, I typically max out HCTZ at 25 mg per day for the treatment of hypertension. If the patient is still not at goal at that dose, I typically add another medication.